However, despite the device-independent APIs, we still have pixel-based content, and "pixel-accurate" graphics. This has made less and less sense over time, with retina displays making pixel-accuracy moot (no more screen fonts!) scaled modes making it impossible and both iOS 7 and OS X 10.10 going for a more geometric look. Still, the design community has resisted, talking about @3 pixel art etc.
The iPhone 6 Plus has a 1920x1080 panel, but the simulator renders at 3x. These two resolutions don't match and so the pixels will need to be downsampled to the display resolution. Whether that is accomplished by downsampling pixel art (which happens automagically with Quartz and the proper device transform set) or as a separate step that downsamples the entire rendered framebuffer doesn't matter (much). Either way, there are no more "pixel perfect" pre-rendered designs.
Device-independent graphics, here we come at last. We're only a quarter century late.
Update: "Its 401 PPI display is the first display I’ve ever used on which, no matter how close I hold it to my eyes, I can’t perceive the pixels. " - John Gruber (emphasis mine)